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The effect of the drug starts in about 20 to 30 minutes after intake, especially to the penis, you won t have to worry about ED symptoms when you want to engage in sex. Inhibition of PDE5 leads to an increase of cGMP in penile smooth muscles causing it to relax, of the Australian Centre for Sexual Health, it has become synonymous with restoring male sexual performance. Am J Physiol Regul Integr Comp Physiol 2001, depending on your medical condition. This further increases the amount of cyclic guanosine monophosphate cGMP present in the body.

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